How long does it take to receive results?

Turnaround time depends on the test: consumer DNA digital re-interpretations take 3–5 business days, while whole exome sequencing takes approximately 30 days from laboratory receipt of your sample. You will receive an email notification when your interactive report is ready in your portal.

What biological samples or files are required?

For our Digital Re-Interpretation service, you can directly upload existing raw DNA data files (such as 23andMe, AncestryDNA, MyHeritage, or clinical BAM/CRAM files). For laboratory sequencing tests, we provide convenient home collection kits or coordinate with certified clinical partner facilities.

How is my genomic data protected and secured?

Your genetic and personal health data is secured with AES-256 and TLS encryption across all stages. We adhere to strict biomedical privacy protocols (HIPAA and GDPR aligned standards). Your genetic data is strictly private and never sold, shared, or transferred to third parties or insurance providers.

Can I delete my genetic data at any time?

Yes. You maintain complete ownership of your genomic files. You can download your raw data and request permanent deletion of your account and biological records at any time via your client portal or by contacting support.

Is a clinical genetics consultation included?

Every clinical whole exome report includes clinical recommendations curated by board-certified medical geneticists. We also provide post-test genetic counseling consultations to help you and your physician integrate findings into your preventative healthcare roadmap.

Can I use results with my existing physician?

Yes. Our clinical reports follow ACMG and CPIC guidelines, structured specifically for treating physicians, oncologists, and cardiologists. You can download full clinical PDF summaries as well as structured machine-readable tables to share directly with your healthcare providers.

What is the turnaround time? Can I take this before scheduled surgery?

Turnaround time is 4–6 weeks for saliva kits, or 10–14 days for raw data interpretation. We recommend ordering testing 1–2 months prior to elective procedures.

What biological sample is required?

A standard non-invasive saliva swab or blood sample.

How are results presented to my surgical team?

Your report includes an executive patient summary and an anesthesiologist-facing clinical card detailing variant classifications, trigger agent contraindications (halothane, sevoflurane, succinylcholine), and recommended safe alternatives.

What happens if a mutation in RYR1 or CACNA1S is detected?

Your anesthesiologist will be informed immediately to administer trigger-free total intravenous anesthesia (TIVA with propofol) and maintain dantrolene availability.

How do genetics affect post-operative pain management?

Polymorphisms in CYP2D6, OPRM1, and COMT determine whether prodrug opioids (codeine, tramadol) are metabolized into active analgesics or cause toxicity, allowing your care team to select precise pain relief.

Are there contraindications for taking the test?

None. Saliva collection is non-invasive and painless.

Can I share the report with my hospital or anesthesiologist?

Yes. You can download an encrypted clinical PDF report and Anesthesia Alert Card directly from your secure Omninome portal to provide to your surgeon.

Which international clinical guidelines are used?

Our algorithms strictly adhere to EMHG (European Malignant Hyperthermia Group), MHAUS (Malignant Hyperthermia Association of the US), CPIC, and FDA standards.

Is international shipping available?

Yes, we provide international courier shipping with prepaid return envelopes.

Genetics of
Safe Anesthesia
& Surgery

24 900 ₽

Pre-operative genetic testing to detect critical risks of malignant hyperthermia, prolonged paralysis, and adverse drug reactions.

Order Test

Why It Matters

Anesthesia is generally safe, but rare and potentially catastrophic hereditary reactions require immediate, informed clinical decisions. Pre-operative genetic screening reveals risks in advance, allowing your surgical team to plan safe, trigger-free anesthesia.

Malignant Hyperthermia

Prolonged Muscle Paralysis

Post-operative Respiratory Depression

Adverse Analgesic Reactions

Genomic Insight Saves
Patient Lives

An anesthesiologist informed by pre-operative genetic risk data can choose safe trigger-free medications and prevent life-threatening perioperative complications.

What We Analyze

Module A

Malignant Hyperthermia Susceptibility

Targeted NGS sequencing of RYR1, CACNA1S, and STAC3 to identify acute hypermetabolic risk triggered by volatile anesthetics

RYR1CACNA1SSTAC3

Module B

Prolonged Neuromuscular Blockade

High-depth screening of BCHE (butyrylcholinesterase) deficiency causing delayed recovery after succinylcholine and mivacurium

BCHE

Module C

Post-Operative Analgesia Response

CPIC-aligned profiling of CYP2D6 and CYP2C9 to guide safe and effective opioid and NSAID pain management protocols

CYP2D6CYP2C9

Detailed Gene Breakdown

RYR1 encodes the intracellular calcium release channel in skeletal muscle sarcoplasmic reticulum. Pathogenic variants trigger uncontrolled calcium release upon exposure to volatile anesthetics, leading to life-threatening hypermetabolic crisis (malignant hyperthermia).

Key Evidence:

Accounts for 50–70% of all malignant hyperthermia cases
Autosomal dominant inheritance
Variable clinical penetrance
50% transmission risk to first-degree offspring

Triggers & Clinical Notes:

Volatile halogenated agents (sevoflurane, desflurane, isoflurane)
Depolarizing neuromuscular blockers (succinylcholine)
Exertional heat stress / strenuous exercise
Mortality exceeds 50% without prompt dantrolene therapy

CACNA1S encodes the alpha-1S subunit of the dihydropyridine receptor, essential for excitation-contraction coupling. Deleterious variants confer malignant hyperthermia susceptibility type 5 and hypokalemic periodic paralysis.

Key Evidence:

Second most frequent locus associated with malignant hyperthermia
May co-occur with atypical RYR1 phenotypes
Severity correlates with specific amino acid substitution

Triggers & Clinical Notes:

Volatile halogenated anesthetics
Succinylcholine

CYP2D6 governs hepatic biotransformation of major perioperative opioids. Ultra-rapid and poor metabolizer phenotypes drastically alter clinical efficacy and respiratory depression risks.

Key Evidence:

Directly affects codeine, tramadol, and oxycodone analgesic activation
Ultra-rapid metabolizers risk severe respiratory depression

Triggers & Clinical Notes:

Codeine
Tramadol
Hydrocodone
Tricyclic antidepressants

Clinical Evidence

1 in 100,000 Adults

carry pathogenic malignant hyperthermia alleles

NCBI Bookshelf: Malignant Hyperthermia

1 in 30,000 Children

exhibit clinical vulnerability to anesthetic crisis

Anesthesiology Clinical Cohort Studies

Up to 25% of Patients

experience suboptimal perioperative pain response due to pharmacogenetic variants

CPIC Guideline Implementation Data

30–40% Reduction

in adverse drug events achieved through pre-operative screening

CPIC & EMHG International Consensus

Pricing & Turnaround

Test price, results turnaround time, and sample kit delivery

$390

Screening cost

Targeted safety genes (RYR1, CACNA1S, BCHE)
Comprehensive clinical report
Board-certified geneticist interpretation

30 days

Turnaround time

From sample accessioning
Secure digital delivery
Actionable surgical clearance summary

Collection Kit

Express delivery included

Non-invasive saliva collection kit
Prepaid return shipping
Global tracked courier

Global Clinical Adoption

Europe (EMHG)

The European Malignant Hyperthermia Group recommends genetic diagnostic protocols for preoperative risk evaluation and guideline adherence

United States (MHAUS)

The Malignant Hyperthermia Association of the United States integrates molecular genetics into perioperative patient safety guidelines

United Kingdom (NHS)

The NHS Genomic Medicine Service provides targeted panels for families with perioperative complications and unexplained surgical events

Global Clinical Practice

Rapidly expanding adoption of preemptive ADME pharmacogenomics across academic surgical centers and outpatient surgery clinics

Who Should Take
This Test

Elective Surgery
Planning

Detect genetic hyperthermia and ADME vulnerabilities beforehand so your surgical team can select trigger-free agents.

Family History of
Anesthesia Events

If relatives experienced unexplained fevers, rigid muscle spasms, or prolonged awakening, genetic testing identifies hereditary risk.

Preemptive Medical
Clearance

Maintain your Anesthesia Alert Card in your digital health wallet for swift decision-making in any emergency surgery.

Post-Surgical Pain
Optimization

Avoid opioid non-response or dangerous sedation by tailoring analgesics to CYP2D6 and CYP2C9 metabolic phenotypes.

Elective Surgery
Planning

Detect genetic hyperthermia and ADME vulnerabilities beforehand so your surgical team can select trigger-free agents.

Family History of
Anesthesia Events

If relatives experienced unexplained fevers, rigid muscle spasms, or prolonged awakening, genetic testing identifies hereditary risk.

Preemptive Medical
Clearance

Maintain your Anesthesia Alert Card in your digital health wallet for swift decision-making in any emergency surgery.

Post-Surgical Pain
Optimization

Avoid opioid non-response or dangerous sedation by tailoring analgesics to CYP2D6 and CYP2C9 metabolic phenotypes.

Elective Surgery
Planning

Detect genetic hyperthermia and ADME vulnerabilities beforehand so your surgical team can select trigger-free agents.

Family History of
Anesthesia Events

If relatives experienced unexplained fevers, rigid muscle spasms, or prolonged awakening, genetic testing identifies hereditary risk.

Preemptive Medical
Clearance

Maintain your Anesthesia Alert Card in your digital health wallet for swift decision-making in any emergency surgery.

Post-Surgical Pain
Optimization

Avoid opioid non-response or dangerous sedation by tailoring analgesics to CYP2D6 and CYP2C9 metabolic phenotypes.

How The Testing
Process Works

Sample Collection

non-invasive saliva or blood

NGS Sequencing

high-coverage clinical sequencing

Interpretation

board-certified medical genetics evaluation

Receive Final Report

with actionable anesthesia alert card

Report Formats

Patient Executive Summary

Written in clear language explaining variant findings without complex jargon. Includes an Anesthesia Alert Card for your surgeon.

Physician Clinical Dossier

Detailed clinical dossier with HGVS nomenclature, transcript IDs, ACMG/AMP classifications, and EMHG/MHAUS guideline citations for anesthesiologists.

Genomics Explained in Clear, Actionable Terms

All your clinical test results are synthesized in one secure portal, while our AI assistant clarifies complex terminology and variant annotations — empowering you to collaborate effectively with your healthcare providers.

Client Portal

All reports and genomic findings in a single dashboard: actionable health priorities and full variant details.

AI Genetic Assistant Nome

Context-aware answers tailored to your genomic data: clear clinical explanations and key questions for your physician.

Interactive Reports Beyond Static PDFs

Engage dynamically with your findings: filter by clinical relevance, navigate risk profiles, and prepare for doctor visits.

The AI assistant does not replace professional medical judgment and is designed for clinical reference and informational guidance.

Часто задаваемые вопросы

Answers to frequently asked questions regarding anesthesia genetics and safety

Secure Your Surgical Anesthesia

Complete clinical genetic screening and provide your anesthesiologist with critical evidence on malignant hyperthermia and drug response risks

Order Test

Genetics ofSafe Anesthesia& Surgery

Why It Matters

Genomic Insight SavesPatient Lives

What We Analyze

Malignant Hyperthermia Susceptibility

Prolonged Neuromuscular Blockade

Post-Operative Analgesia Response

Detailed Gene Breakdown

Clinical Evidence

Pricing & Turnaround

Global Clinical Adoption

Europe (EMHG)

United States (MHAUS)

United Kingdom (NHS)

Global Clinical Practice

Who Should TakeThis Test

Elective SurgeryPlanning

Family History ofAnesthesia Events

Preemptive MedicalClearance

Post-Surgical PainOptimization

Elective SurgeryPlanning

Family History ofAnesthesia Events

Preemptive MedicalClearance

Post-Surgical PainOptimization

Elective SurgeryPlanning

Family History ofAnesthesia Events

Preemptive MedicalClearance

Post-Surgical PainOptimization

How The TestingProcess Works

Report Formats

Genomics Explained in Clear, Actionable Terms

Client Portal

AI Genetic Assistant Nome

Interactive Reports Beyond Static PDFs

Часто задаваемые вопросы

Secure Your Surgical Anesthesia

Genetics of
Safe Anesthesia
& Surgery

Genomic Insight Saves
Patient Lives

Who Should Take
This Test

Elective Surgery
Planning

Family History of
Anesthesia Events

Preemptive Medical
Clearance

Post-Surgical Pain
Optimization

Elective Surgery
Planning

Family History of
Anesthesia Events

Preemptive Medical
Clearance

Post-Surgical Pain
Optimization

Elective Surgery
Planning

Family History of
Anesthesia Events

Preemptive Medical
Clearance

Post-Surgical Pain
Optimization

How The Testing
Process Works